b, Strain induced in the brain during insertion of the folded electrode array for two different brain hemisphere spacings. a, A diagram that shows parameter definitions for insertion model of folded electrode array. Folded electrode mechanical modeling results. Complete schematics of the custom data acquisition interface circuit board. This circuit is repeated 20 times, one for each column of the electrode array. Block diagram of constant current sink implementation. b, Photograph of custom data acquisition interface circuit board that generates row select signals and provides another stage of buffering (top) and c, (bottom).
a, Photograph of custom circuit board that implements the off array constant current sinks, buffering and high-pass filtering. Photographs of data acquisition system components. Circuit diagram of four unit cells, showing multiplexing connections. The spikes in clusters 2, 4, 12, 14, and 19 appeared to occur almost exclusively during seizures, while spikes in the other clusters appeared to occur uniformly throughout the record. Delay maps for all of the spikes in each cluster indicated a strong similarity within clusters. The resulting power spectra were averaged to produce a single overall power spectral density. The power spectral density was calculated using ‘pwelch’ with a window size of 1024 on each channel of the electrode array individually. The primary frequency component was 6 Hz.
Analysis of the frequency content of a sustained, counterclockwise spiral during a short seizure. b, Individual visual evoked responses shown for the 49 electrodes located in the bottom, lieft-hand corner of the electrode array, as highlighted by the dashed box above.
Data are anatomically orientated as shown in the inset of Figure 3b. a, Spatial distribution of the visual evoked response, as determined by the root-mean-square (RMS) value of the zero-meaned signal within the 40 ms to 160 ms window after the stimulus. A single-trial visual evoked potential from a full-field drifting grating. b, schematic cross-sectional information, red dotted line shows the location of neutral mechanical plane (NMP). Schematic of fabrication steps a, Microscope images of each fabrication step.
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